The Binding of Isaac: A Mochi.TV Presentation

Isaac, a small boy trapped beneath his hilltop home, descends through a dark multi-floor labyrinth after fleeing his mother. Each floor holds a treasure room, a boss monster, and one of his confiscated possessions, while a fatherly voice names items and awakens abilities. Isaac survives with tears that damage enemies, seeking salvation in the largest treasure chest buried deepest below.